Table 1. COPs are overexpressed and implicated in the pathophysiology of a number of cancer lineages.
Tumor Type | COPA | COPB1 | COPB2 | COPG1 | COPG2 | COPD | COPE | COPZ1 | COPZ2 |
Bladder | 10−7 | ||||||||
Pancreatic | |||||||||
Cervical | |||||||||
Breast | 10−11 | 10−9 | 10−9 | 10−20 | |||||
Liver | |||||||||
HN | |||||||||
Lymphoma | |||||||||
Prostate | 10−9 | 10−7 | 10−6 | ||||||
Sarcoma | 10−11 | ||||||||
Lung | |||||||||
Brain, CNS | |||||||||
Colorectal | 10−17 | 10−10 | 10−8 | 10−13 | |||||
Ovarian | 10−8 | 10−15 | |||||||
Kidney |
Aberrations with P≤10–6 are indicated. Data are derived from a reanalysis of Bittner Multicancer Dataset (www.oncomine.org). HN, Head and Neck; CNS, Central Nervous System.