Table 1.
Significantly mutated genes identified in 46 whole genome and 31 exome sequenced luminal breast cancer patients.
| Gene | Total | MS | NS | Indel | SS | P-value | FDR |
|---|---|---|---|---|---|---|---|
| MAP3K1 | 13 | 2 | 3 | 8 | 0 | 0 | 0 |
| PIK3CA | 45 | 44 | 0 | 1 | 0 | 0 | 0 |
| TP53 | 18 | 13 | 1 | 1 | 1 | 0 | 0 |
| GATA3 | 8 | 1 | 0 | 4 | 3 | 1.15E-19 | 7.41E-16 |
| CDH1 | 8 | 1 | 1 | 5 | 1 | 3.07E-15 | 1.59E-11 |
| TBX3 | 4 | 0 | 0 | 3 | 0 | 2.58E-06 | 0.011 |
| ATR | 6 | 6 | 0 | 0 | 0 | 3.73E-06 | 0.014 |
| RUNX1 | 4 | 4 | 0 | 0 | 0 | 6.59E-06 | 0.021 |
| ENSG00000212670 | 2 | 2 | 0 | 0 | 0 | 2.31E-05 | 0.066 |
| RB1 | 4 | 2 | 1 | 0 | 1 | 2.76E-05 | 0.071 |
| LDLRAP1 | 2 | 1 | 1 | 0 | 0 | 4.27E-05 | 0.092 |
| STMN2 | 2 | 1 | 0 | 1 | 0 | 4.15E-05 | 0.092 |
| MYH9 | 4 | 1 | 1 | 2 | 0 | 8.96E-05 | 0.178 |
| MLL3 | 5 | 1 | 1 | 3 | 0 | 0 | 0.191 |
| CDKN1B | 2 | 0 | 1 | 1 | 0 | 0 | 0.240 |
| AGTR2 | 2 | 2 | 0 | 0 | 0 | 0 | 0.256 |
| SF3B1 | 3 | 3 | 0 | 0 | 0 | 0 | 0.256 |
| CBFB | 2 | 1 | 1 | 0 | 0 | 0 | 0.256 |
Footnote:
*
ENSG00000212670 is not in RefSeq release 50.
MS = Missense, NS = Nonsense, SS = Splice Site.