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. Author manuscript; available in PMC: 2012 Jun 26.
Published in final edited form as: Science. 2011 Oct 28;334(6055):528–531. doi: 10.1126/science.1210558

Figure 1.

Figure 1

Postprandial cardiac growth in the python is characterized by cellular hypertrophy and activation of protein synthesis pathways. (A) Masson trichrome–stained python hearts depicting pronounced postprandial cardiac hypertrophy. Scale bar = 2 mm (B) BrdU-staining of 0 and 3 DPF python hearts shows no evidence of postprandial cellular proliferation (python small intestine is included as a positive control [brown nuclear staining]) Scale bar = 50 µm (C) The number of nuclei per field is reduced post-feeding. (D) Immunoblot analysis reveals increased phosphorylation of AMPK, Akt, GSK3β, and mTor in the postprandial python heart. Error bars represent ±SE; n=4 per condition; *p<0.05 versus 0 DPF.