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. Author manuscript; available in PMC: 2012 Jun 26.
Published in final edited form as: Science. 2011 Oct 28;334(6055):528–531. doi: 10.1126/science.1210558

Figure 4.

Figure 4

Postprandial python plasma fatty acids induce cardiac growth in vivo. (A) Infusing fasted pythons with fed plasma or C14:0, C16:0, and C16:1n7 (FAs) results in increased heart mass (heart weight/body weight) comparable to that seen with ingestion of a rodent meal (3 DPF). (B) Seven day infusion of FAs in mice results in increased left ventricular mass (left ventricular mass/tibia length) and increased relative myocyte cross-sectional area. (C) FA infusion in mice results in increased MYH6 (α-myosin heavy chain) mRNA expression with no change in MYH7 (β-myosin heavy chain) or atrial natriuretic factor (ANF). Error bars represent ±SE; n=3 (A) or 6 (B and C) per condition; *p<0.05 versus fasted python (A); *p<0.05 versus BSA (B and C).