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. Author manuscript; available in PMC: 2012 Jun 26.
Published in final edited form as: Front Biosci. 2012 Jun 1;17:2476–2494. doi: 10.2741/4066

Figure 4.

Figure 4

Modeled sTF interactions with the EGF1 domain of FXa, FIXaand FIXalpha. The interacting residues between sTF (magenta) and EGF1 (wheat) are shown in stick representation. The carbon atoms are magenta in sTF, and wheat in FVIIa-EGF1. The N and O atoms are blue and red, respectively. The black dashed lines represent hydrogen bonds between the interacting residues. A) The modeled interaction between FXa-EGF1 domain and sTF. FXa-EGF1:sTFs—C50:N199, E51:K15, T52:T13, S53:E105, N57:E99, Q58:T101 and K60:T197 B) The modeled interaction between FIXa-EGF1 domain and sTF. FIXa-EGF1:sTFs—E52:K15/N107, N54:N199/E105 and N58:E99. C) The modeled interaction between FIXalpha-EGF1 domain and sTF. FIXalpha-EGF1:sTFs—D49:K165, N54:K169, K63:Y157 and D64:K166.