Table 2.

Race and the site-specific risk of second primary cancers in renal cell carcinoma

Site of second malignancy	Whites (O, SIR)	Blacks (O, SIR)	Others (O, SIR)†
All sites	3,230 (1.15)*	382 (1.38)*	182 (1.7)
All solid tumors	2,897 (1.15)*	355 (1.4)*	167 (1.73)
All lymphatic and Hematopoietic diseases	263 (1.17)*	20 (1.14)	15 (2.01)*
Oral cavity and pharynx	50 (0.74)*a	3 (0.44)	1 (0.4)
Digestive system	605 (1.06)b	59 (0.96)h	54 (1.7)*l
Liver, GB IHBD, EHBD, other biliary	51 (1.2)c	3 (0.6)	3 (0.55)
Respiratory system	474 (0.99)d	69 (1.3)i	19 (1.1)m
Bones and Joints	4 (1.7)	0 (0)	0 (0)
Soft tissue including heart	12 (1.0)	3 (3.0)	0 (0)
Skin excluding BCC and SCC	120 (1.23)*e	0 (0)	1 (1.5)
Breast	216 (0.93)	0 (0)	10 (1.4)
Female Genital system	88 (0.96)	5 (0.6)	3 (0.98)
Male Genital system	751 (1.16)*f	102 (1.3)*j	43 (1.9)*n
Urinary bladder	217 (1.22)*	15 (2.0)*	10 (2.53)*
Kidney	251 (4.01)*	65 (9.9)*	18 (8.1)*
Renal pelvis	4 (0.6)	1 (3.1)	0 (0)
Ureter	10 (2.1)	0 (0)	0 (0)
Eye and Orbit	4 (0.91)	0 (0)	0 (0)
Brain and other Nervous system	30 (1.03)	1 (0.7)	1 (1.4)
Endocrine system	57 (3.1)*g	6 (3.9)k	7 (5.3)*o
Lymphoma	125 (1.1)	10 (1.55)	8 (1.9)
Myeloma	45 (1.3)	4 (0.6)	1 (0.8)
Leukemia	93 (1.21)	6 (1.2)	6 (.9)*p
Mesothelioma	11 (1.2)	0 (0)	0 (0)
Kaposi Sarcoma	3 (0.93)	0 (0)	0 (0)
Miscellaneous	58 (0.84)	7 (0.98)	0 (0)

^*p<0.05

^† American Indian, Alaskan Native, Native American, Asian and Pacific Islander

^aRisk of SPC in the hypopharynx significantly decreased (SIR, 0.16);

^bRisk of SPC in the hepatic flexure of the colon (SIR: 1.7) significantly increased;

^cRisk of SPC in the pancreas significantly increased (SIR: 1.33);

^dRisk of SPC in the larynx significantly decreased (SIR: 0.16);

^eRisk of melanoma of the skin significantly increased (SIR: 1.22);

^fRisk of SPC in the prostate significantly increased (SIR: 1.16);

^gRisk of SPC in the thyroid gland (SIR: 3.01) and adrenal gland (SIR: 7.3) significantly increased;

^hRisk of SPC in the small intestine and transverse colon significantly increased (SIR: 3.4 and 3.05 respectively);

ⁱRisk of SPC in the lung and bronchus significantly increased (SIR: 1.4);

^jRisk of SPC in the prostate gland significantly increased (SIR: 1.3);

^kRisk of SPC in the thyroid gland significantly increased (SIR: 4.7);

^lRisk of SPC in the colon (excluding the rectum, SIR:2.25), specifically in the hepatic (SIR:5.2) and splenic flexures (SIR: 7.7) and the sigmoid colon (SIR:2.3), rectum and rectosigmoid junction (SIR:2.22) is significantly increased;

^mRisk of SPC in the trachea (SIR: 84.3) significantly increased;

ⁿRisk of SPC in the prostate significantly increased (SIR: 1.87);

^oRisk of SPC in thyroid gland significantly increased (SIR: 6.0);

^pRisk of ALL (SIR: 17.6) significantly increased;