Table 6.

Kaplan Meier analysis of factors influencing overall survival in renal cell carcinoma patients with second primary cancers

Factor tested	Patient group	N	Mean survival (±SE)	95% C.I.	χ2	Log Rank test (Mantel-Cox)
Age at diagnosis of RCC	<60 years	1,119	222±4.5 months	213.5–221 months	356.7	P<0.001
	≥60 years	2,253	130±2.0 months	126–134 months
Age at occurrence of SPC	<60 years	538	198.6±8 months	184–213.5 months	26.8	P<0.001
	≥60 years	2,834	158±2.4 months	153–162 months
Race	White	2,871	164±2.5 months	159.5–169 months	8.7	P=0.013
	Black	340	141±6.3 months	129–154 months
	Othersa	160	164±9.5 months	145.6–183 months
Gender	Male	2,395	162±4 months	154–170 months	0.005	P=0.95
	Female	977	163±2.8 months	157–168 months
Marital status at time of diagnosis of RCC	Married	2,463	171±2.8 months	166–178.5 months	65.4	P<0.001
	Widowed	358	119±5 months	109–129 months
	Divorced	188	150±8 months	133–166 months
	Separated	244	155±8.5 months	1390172 months
	Single (Never married)	25	155±19 months	118.5–192 months
Summary stage (2004+)	Localized	404	79.5±1.8 months	76–83 months	84.5	P<0.001
	Regional	82	74±4 months	66–82 months
	Distant	34	30.5±1.7 months	19.1–42 months
Grade of RCC	Well differentiated	350	184±8 months	168.6–200 months	15.5	0.001
	Moderately differentiated	610	143.5±4.5 months	134.6–152 months
	Poorly differentiated	194	149±10 months	129–169.5 months
	Undifferentiated	31	143±23 months	99–188 months
Size of primary renal tumor	≤5cm	989	131±2.5 months	126–136 months	0.78	0.67
	>5cm-≤10cm	702	129±3.0 months	123–135 months
	>10cm	157	124±6.5 months	112–137 months
Laterality	Right origin of primary	1,712	158±3 months	152–164 months	3.9	0.048
	Left origin of primary	1,632	168±3.5 months	161.5–175 months
Radiation therapy given?	Yesc	99	119±11 months	98–141 months	15.3	P<0.001
	No	3,255	164±2.4 months	159.5–169 months
Radiation sequence with surgery	Received both	80	131±12 months	108–154 months	6.7	0.01
	Received neither	3,291	163.6±2.4 months	159–168 months
Months between diagnosis of FPC and SPC	0–11 months	613	92.6±4.7 months	83.5–102 months	756.1	P<0.001
	12–59 months	1,093	120±3.6 months	113–127 months
	≥ 60 months	1,666	210±2.3 months	204–216 months

Number of patients (N), only primary cancer (OPC), Secondary primary cancer (SPC), Well differentiated (WD), moderately differentiated (MD), poorly differentiated (PD),

^aBlack, American Indian, Alaskan Native, Asian, Pacific islander

^bRegional or distant spread of tumor

^cReceived either radiation or radioisotope therapy