Table 3.

The association of retinal vessel caliber with any cardiovascular disease Univariate Multivariate^*

			Univariate		Multivariate*
Retinal Vessel Caliber§	n	Any CVD (%)	OR (95% CI)	p-value†	OR (95% CI)	p-value†
Arteriole diameter, All patients
1st Quartile (Lowest	399	133 (33.3%)	1.00	0.69	1.00	0.25
2nd Quartile	400	124	(31.0%)	0.90 (0.67 - 1.21)	0.82 (0.58 - 1.14)
3rd Quartile	400	121 (30.3%)	0.87 (0.64 - 1.17)		0.90 (0.64 - 1.27)
4th Quartile (Highest)	400	140 (35.0%)	1.08 (0.80 - 1.44)		1.19 (0.85 - 1.69)
Vein diameter, All patients
1st Quartile	399	129 (32.3%)	1.00	0.02	1.00	0.01
2nd Quartile	400	107 (26.8%)	0.76 (0.56 - 1.04)		0.87 (0.61 - 1.23)
3rd Quartile	400	127 (31.8%)		0.97 (0.72 - 1.31)	1.15 (0.82 - 1.62)
4th Quartile	400	155 (38.8%)	1.32 (0.99 - 1.77)		1.47 (1.03 - 2.08)
Arteriole diameter, Diabetic patients
1st Quartile	148	77 (52.0%)	1.00	0.28	1.00	0.48
2nd Quartile	167	66 (39.5%)	0.60 (0.39 - 0.94)		0.51 (0.31 - 0.84)
3rd Quartile	163	61 (37.4%)	0.55 (0.35 - 0.87)		0.58 (0.35 - 0.96)
4th Quartile	189	88 (46.6%)	0.80 (0.52 - 1.24)		0.80 (0.49 - 1.31)
Vein diameter, Diabetic patients
1st Quartile	152	68 (44.7%)	1.00	0.25	1.00	0.10
2nd Quartile	139	51 (36.7%)	0.72 (0.45 - 1.15)		0.74 (0.44 - 1.23)
3rd Quartile	176	74 (42.0%)	0.90 (0.58 - 1.39)		1.03 (0.63 - 1.66)
4th Quartile	200	99 (49.5%)	1.21 (0.79 - 1.85)		1.38 (0.85 - 2.26)

CVD=Cardiovascular disease. OR=Odds ratio. CI=Confidence interval.

^§Based on mean of both eyes

^†p-value is for test of linear trend

^*Adjusted by Age, Sex, Low-density Lipoprotein, High-density Lipoprotein, Systolic blood pressure, Smoking Status, Diabetes, Hypertension, Hemoglobin A1C, Triglycerides, eGFR, and log of 24H Urine Protein