. Author manuscript; available in PMC: 2013 Sep 1.

Published in final edited form as: Adv Drug Deliv Rev. 2012 Mar 10;64(12):1177–1188. doi: 10.1016/j.addr.2012.03.002

Table 1.

Nitric oxide release data from NO donors.

NO donor	Donor type	NO release half-life	Experimental parameters	Total NO (μmol mg⁻¹)
PROLI/NO	N-diazeniumdiolate	1.8 s [16]	pH 7.4, 37 °C	7.97^a
DETA/NO	N-diazeniumdiolate	20 h [16]	pH 7.4, 37 °C	12.25^a
PAPA/NO	N-diazeniumdiolate	15 min [16]	pH 7.4, 37 °C	11.35^a
CBC-NO	N-diazeniumdiolate	31 min^b [47]	pH 7.4, 37 °C	0.05 [47]
PEIC-NO	N-diazeniumdiolate	16 h [128]	pH 7.4, 37 °C	0.0685 [128]
SNAP	S-nitrosothiol	1.7 h [169]	pH 7, 37 °C, 50 mM tris-HCl, 10 mM, in dark	4.54^a
GSNO	S-nitrosothiol	3 h^c [170]	pH 7.4, 37 °C, in dark	2.97^a
SNO-BSA	S-nitrosothiol	5 h [91]	pH 7.4, 37 °C, 0.3 mM, in dark	0.227 [171]
Nitroglycerin	Organic nitrate	N/A^d		13.21^a
Nitroparacetamol	Organic nitrate	N/A^d		3.57^a
Nitroflurbiprofen	Organic nitrate	N/A^d		2.77^a
Nitronaproxen	Organic nitrate	N/A^d		2.88^a
SNP	Metal nitrosyl	N/A^d		3.82^a
NPR	Metal nitrosyl	N/A^d		2.59^a

Theoretical total NO release based on chemical structure

Approximated by assuming first-order kinetics and 6 half-lives (95% decay)

Calculated from second order rate constant with 5 mM GSNO

Organic nitrates and metal nitrosyls do not spontaneously release NO at physiological pH and temperature