Table 1.
NO donor | Donor type | NO release half-life | Experimental parameters | Total NO (μmol mg−1) |
---|---|---|---|---|
PROLI/NO | N-diazeniumdiolate | 1.8 s [16] | pH 7.4, 37 °C | 7.97a |
DETA/NO | N-diazeniumdiolate | 20 h [16] | pH 7.4, 37 °C | 12.25a |
PAPA/NO | N-diazeniumdiolate | 15 min [16] | pH 7.4, 37 °C | 11.35a |
CBC-NO | N-diazeniumdiolate | 31 minb [47] | pH 7.4, 37 °C | 0.05 [47] |
PEIC-NO | N-diazeniumdiolate | 16 h [128] | pH 7.4, 37 °C | 0.0685 [128] |
SNAP | S-nitrosothiol | 1.7 h [169] | pH 7, 37 °C, 50 mM tris-HCl, 10 mM, in dark | 4.54a |
GSNO | S-nitrosothiol | 3 hc [170] | pH 7.4, 37 °C, in dark | 2.97a |
SNO-BSA | S-nitrosothiol | 5 h [91] | pH 7.4, 37 °C, 0.3 mM, in dark | 0.227 [171] |
Nitroglycerin | Organic nitrate | N/Ad | 13.21a | |
Nitroparacetamol | Organic nitrate | N/Ad | 3.57a | |
Nitroflurbiprofen | Organic nitrate | N/Ad | 2.77a | |
Nitronaproxen | Organic nitrate | N/Ad | 2.88a | |
SNP | Metal nitrosyl | N/Ad | 3.82a | |
NPR | Metal nitrosyl | N/Ad | 2.59a |
Theoretical total NO release based on chemical structure
Approximated by assuming first-order kinetics and 6 half-lives (95% decay)
Calculated from second order rate constant with 5 mM GSNO
Organic nitrates and metal nitrosyls do not spontaneously release NO at physiological pH and temperature