Table 1.
Synthetic genetic interactions of cse4-R37A with mutations in genes encoding kinetochore components
| Kinetochore component/complex | Allele | Synthetic phenotype with cse4-R-37A* |
| CENP-C | mif2-3 | — |
| Cbf1 | cbf1Δ | Growth defect |
| CBF3 complex | cep3-1, cep3-2 | — |
| ndc10-1 | Slight growth defect | |
| ndc10-2 | — | |
| Ctf19 complex | ctf19Δ | Lethality |
| okp1-5 | Growth defect | |
| mcm21Δ | Lethality | |
| ame1-4 | Lethality | |
| iml3Δ/mcm19Δ | Growth defect | |
| chl4Δ | Growth defect | |
| ctf3Δ/chl3Δ | Growth defect | |
| Mtw1/MIND complex | mtw1-11 | Slight growth defect |
| Ndc80 complex | ndc80-1 | — |
| spc25-1 | — | |
| spc24-1 | — | |
| Knl1 complex | spc105-4 | Slight growth defect |
| Kinesin motor protein | cin8Δ | Lethality |
| Replication fork-associated factor | csm3Δ | — |
*Additional phenotype caused by cse4-R37A in combination with the indicated allele of the gene encoding the respective kinetochore component. —, no additional phenotype observed.