Fig. 5.

Proposed mechanism for propagation of the arginine-to-cysteine change at position 112 (in yellow) to the structural differences between apoE3 and apoE4 via Arg114 (blue) and His140 (green). In helix 4, arginines and lysines are shown in blue and aspartate is shown in red. Peptide 271–279 is shown in red, and peptide 5–21 is shown in orange; these are the peptides that are structurally different between apoE3 and apoE4. The pink lines connect pairs of residues that lie within 6 Å between helix 4 and the peptides.