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. 2012 May 7;109(23):8919–8924. doi: 10.1073/pnas.1202435109

Fig. 2.

Fig. 2.

Effects of APPL1 deficiency on glucose tolerance and insulin secretion in mice. (A) GTT in 20-wk-old male APPL1 KO and WT littermates fed with HFD or STC. (B) In vivo GSIS in APPL1 KO mice and WT littermates fed with STC or HFD (fold change over basal insulin level). (C) Glucose- and KCl-stimulated static insulin secretion in islets isolated from 20-wk-old male APPL1 KO mice and WT controls on STC. Insulin concentration was measured at 30 min after stimulation. (D) Dynamic insulin secretion of pancreatic islets isolated from APPL1 KO and WT mice in response to glucose (25 mM) using a perifusion system. (E) Area under curve (AUC) for the first phase (6–18 min) and second phase (18–42 min) of insulin secretion during the perifusion experiment as in D. *P < 0.05 (n = 6–8). NS, not significant.