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. 2012 May 7;109(23):8919–8924. doi: 10.1073/pnas.1202435109

Fig. 3.

Fig. 3.

Transgenic expression of APPL1 improves glucose tolerance and insulin sensitivity and enhances insulin secretion in HFD-fed obese mice. (A) Western blot analysis for APPL1 expression in isolated pancreatic islets of 12-wk-old male APPL1 transgenic (Tg) mice and WT littermates. (B) GTT in 16-wk-old APPL1 Tg mice and WT littermates fed with either STC or HFD. (C) In vivo GSIS in 16-wk-old male mice, and plasma insulin level was expressed as fold change over the baseline. (D and E) Static insulin secretion in response to glucose and KCl stimulation in islets from 20-wk-old APPL1 Tg and WT littermates on STC or HFD, respectively. (F) ITT in 20-wk-old APPL1 Tg mice and WT littermates fed with either STC or HFD. *P < 0.05 (n = 6–7).