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Enzymatic activity of HAT1. (A) Mass spectrometry results of HAT1 activity at different time points. Peaks are labeled that correspond to unmodified peptide (H4) as well as to mono- or di-acetylated peptide (H4 + Ac1 or H4 + Ac2). pH profile of wild-type (B) and mutant forms of HAT1 (C).
