Fig. 1.

Surgical removal of the parametrial fat pads inhibits UVB-induced skin tumor formation In mice fed a high-fat diet, but not in mice fed a regular low-fat chow diet. (A) Eighty female SKH-1 mice were given a 40%-kcal high-fat diet rich in omega-6 fatty acids as described by Reddy et al. (56) for 2 wk, and (B) another 80 female SKH-1 mice were given a low-fat chow diet for 2 wk. Mice on each diet were then equally divided into two groups. One group of mice had their parametrial fat pads removed and the other group of mice was a sham-operated control. The high-fat and the chow diets were continued throughout the study. Two weeks after the surgery, all of the mice were treated with UVB (30 mJ/cm²) twice a week for 33 wk. Body weight and tumors were measured every 2 wk.