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. 2012 May 8;109(23):9161–9166. doi: 10.1073/pnas.1202916109

Fig. 3.

Fig. 3.

PKG-I inhibition prevents H2S-induced in vitro angiogenesis. (A) bEnd3 cells were pretreated with vehicle, DT-2 peptide (1 μM, 20 min), or the control peptide (TAT) (1 μM, 20 min) and then stimulated with NaHS (30 μM) to induce cell proliferation. The effect of DT-2 on NaHS-induced response was also estimated in wound healing (B) and cell migration (C). **P < 0.01 vs. control; ##P < 0.01 vs. NaHS + TAT. (D) Aortic ring explants were embedded in collagen gel, treated with the control peptide (TAT) or DT-2 (1 μM), and cultured for 7 d in the presence or absence of NaHS (30 μM, applied every 8 h). P < 0.01 vs. control; ##P < 0.01 vs. NaHS + TAT.