Figure 6.

Effects of synthetic inulin and fluvastatin on expression of cytochrome P450 proteins [levels] in SD or HF diet-fed rats. Rats (7 weeks of age) were fed the SD, SD + I, HF, or HF + I diet for 1 week, and then administered fluvastatin (0 or 4 mg/kg) with the diet daily. The rats were sacrificed 14 days after starting the administration of fluvastatin. The microsome proteins (20 μg/lane) were prepared and subjected to immunoblot analysis. The signal intensities were determined with CS analyzer (ATTO Densitograph Software Library). Relative levels are expressed by taking the control values obtained from SD-fed control animals as 100. Values are the mean ± S.E. of 3 determinations. *p < 0.05, **p < 0.01, ***p < 0.001 versus SD-fed control rats; ##p < 0.01, ###p < 0.001 versus HF-fed control rats.