Table 1: Body of Evidence Examined According to Study Design*.
| Study Design | Number of Eligible Studies |
|---|---|
| RCT Studies | |
| Systematic review of RCTs | 6† |
| Large RCT‡ | 3 |
| Small RCT | 4§ |
| Observational Studies | |
| Systematic review of non-RCTs with contemporaneous controls | |
| Non-RCT with contemporaneous controls | |
| Systematic review of non-RCTs with historical controls | |
| Non-RCT with historical controls | |
| Database, registry, or cross-sectional study | |
| Case series | |
| Retrospective review, modelling | |
| Studies presented at an international conference or other sources of grey literature | |
| Expert opinion | |
| Total | 13 |
*
Abbreviations: RCT, randomized controlled trial.
†
Includes 1 health technology assessment and 5 systematic reviews.
‡
Large RCT was defined as a trial with more than 100 patients.
§
Two of the small RCTs reported results for the same study.