Figure 2.

HPLC chromatograms of (A) blank plasma, (B) blank feces, (C) blank urine, (D) blank serosal fluid, (E) blank sac tissue, (F) plasma sample obtained from the jugular vein at 30 minutes after HMw-NPC administration (50 mg/kg, orally), (G) feces, and (H) urine samples collected by metabolic cages at 12–24 hours after HMw-NPC administration (50 mg/kg, orally), (I) serosal fluid, and (J) sac tissue samples incubated HMw-NPC at 100 μg/mL for 60 minutes. Peak 1, 2-(4′-hydroxybenzeneazo)benzoic acid (as internal standard); peak 2, curcumin.

Abbreviation: HMw-NPC, curcumin encapsulated in high molecular weight PLGA.