Table 7: Summary of Results − Abstinence at Longest Follow-Up*.
| Intervention | Comparison | Number of Studies | Abstinence Rate Pooled Relative Risk (95% CI) |
GRADE |
|---|---|---|---|---|
| Counselling | Usual Care | 2 | 5.85 (3.81−8.97)† | Moderate |
| Intensive Counselling ≥ 90 minutes | Usual Care | 1 | 7.70 (4.64−12.79)† | |
| Minimal Counselling < 90 minutes | Usual Care | 1 | 1.56 (0.65−3.72) | |
| Counselling + NRT | Usual Care | 3 | 4.28 (3.51−5.20)† | Moderate |
| Intensive Counselling ≥ 90 minutes + | Usual Care | |||
| NRT | Usual Care | 1 | 4.41 (3.60−5.39)† | |
| Minimal Counselling < 90 minutes + NRT | 2 | 2.11 (0.90−4.91) | ||
| Minimal Counselling < 90 minutes + Antidepressant | Usual Care | 1 | 1.91 (0.65−5.61) | Low |
| Minimal Counselling < 90 minutes + NRT + Antidepressant | Usual Care | 1 | 2.25 (0.87−5.85) | Low |
| NRT | Placebo | 1 | 3.01 (1.02−8.89)† | Moderate |
| Antidepressant | Placebo‡ | 2 | 2.09 (1.35−3.24)† | Moderate |
| Nortriptyline | Placebo | 1 | 2.54 (0.87−7.44) | Moderate |
| Bupropion | Placebo | 2 | 2.01 (1.24−3.24)† |
*
Abbreviations: CI, confidence interval; NRT, nicotine replacement therapy.
†
Statistically significant (P < 0.05).
‡
One study had 2 treatment arms, each examining a different antidepressant.