Table 1: Body of Evidence Examined According to Study Design*.
| Study Design | Number of Eligible Studies |
|---|---|
| Randomized Controlled Trials | |
| Systematic review of RCTs | 2 |
| Large RCT† | - |
| Small RCT | - |
| Observational Studies | |
| Systematic review of non-RCTs with contemporaneous controls | 1 |
| Non-RCT with contemporaneous controls | - |
| Systematic review of non-RCTs with historical controls | - |
| Non-RCT with historical controls | - |
| Database, registry, or cross-sectional study | - |
| Case series | - |
| Retrospective review, modelling | - |
| Studies presented at an international conference or other sources of grey literature | - |
| Expert opinion | - |
| Total | 3 |
*
Abbreviation: RCT, randomized controlled trial.
†
Large RCT ≥ 150 subjects.