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. 2012 Apr 17;21(14):3156–3172. doi: 10.1093/hmg/dds142

Figure 2.

Figure 2.

Enlarged endosomes are present in LCLs from individuals with DS. (A) Representative confocal images of EEA1-positive early endosomes of LCLs from euploids and individuals with DS. (B) Mean number of EEA1-positive early endosomes in DS (n= 12) when compared with euploids (n= 9) LCLs. (C) Mean endosome size in LCLs from DS when compared with euploids. (D) Endosome size distribution of small-, medium- and large-sized endosomes, based on K-means clustering. (E) Representation of LCLs from euploid (green circles) and individuals with DS (red circles) in the plane defined by the percentage of their large and small endosomes. ***P< 0.001.