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. 2012 Apr 17;21(14):3156–3172. doi: 10.1093/hmg/dds142

Figure 6.

Figure 6.

Downregulation of SYNJ1 expression in DS fibroblasts by shRNA partially rescues enlarged endosome phenotype. (A) Representative confocal images of EEA1-positive early endosomes (red) from euploid and DS fibroblasts transfected with random-shRNA (green) or SYNJ1-shRNA plasmid (green). (B) Mean number of EEA1-positive early endosomes from euploid and DS fibroblasts transfected with random-shRNA or SYNJ1-shRNA. (C) Mean endosome size from euploid and DS fibroblasts transfected with random-shRNA or SYNJ1-shRNA. (D) Endosome size distribution into small-, medium- and large-sized endosomes, based on K-means clustering. ***P< 0.0001.