Table 3.
Predictive factors of QOL-E scores
| QOL index* | Factor | Univariate analysis | Multivariate analysis† | |||
|---|---|---|---|---|---|---|
|
| ||||||
| Effect (95% CI)‡ | p value | Effect (95% CI)‡ | p value | |||
| QOL-E, Physical | Age (1 year) | -0.73 (-1.00, -0.46) | <0.0001 | -0.48 (-0.74, -0.22) | 0.0003 | |
| Charlson’s index (2-5 vs 0-1)§ | -16.3 (-23.0, -9.5) | <0.0001 | -14.2 (-20.4, -8.0) | <0.0001 | ||
| Hb (1 g/dL)║ | +2.48 (+1.50, +3.45) | <0.0001 | +1.69 (+0.71, +2.67) | 0.0008 | ||
| Transfusions (yes vs no)¶ | -9.1 (-13.6, -4.7) | 0.0002 | -7.2 (-11.7, -2.6) | 0.0029 | ||
| Time from baseline (1 month) | -0.22 (-0.45, +0.01) | 0.061 | -0.29 (-0.52, -0.06) | 0.014 | ||
|
| ||||||
| QOL-E, Functional | Age (1 year) | -0.34 (-0.66, -0.01) | 0.042 | -0.01 (-0.33, +0.30) | 0.93 | |
| Charlson’s index (2-5 vs 0-1)§ | -14.8 (-22.6, -7.1) | 0.0002 | -15.5 (-22.9, ‐8.1) | <0.0001 | ||
| Hb (1 g/dL)║ | +3.79 (+2.49, +5.09) | <0.0001 | +2.99 (+1.61, +4.36) | <0.0001 | ||
| Transfusions (yes vs no)¶ | -13.0 (-19.3, -6.6) | 0.0002 | -8.3 (-15.1, -1.6) | 0.017 | ||
| Time from baseline (1 month) | -0.10 (-0.47, +0.27) | 0.60 | -0.21 (-0.59, +0.16) | 0.26 | ||
|
| ||||||
| QOL-E, Social | Age (1 year) | -0.46 (-0.83, -0.08) | 0.017 | -0.26 (-0.63, +0.11) | 0.17 | |
| Charlson’s index (2-5 vs 0-1)§ | -15.3 (-24.4, -6.3) | 0.0011 | -15.6 (-24.3, -6.9) | 0.0005 | ||
| Hb (1 g/dL)║ | +2.42 (+1.10, +3.74) | 0.0003 | +2.15 (+0.79, +3.52) | 0.0021 | ||
| Transfusions (yes vs no)¶ | -8.1 (-14.2, -2.1) | 0.0098 | -6.7 (-12.9, -0.4) | 0.037 | ||
| Marital status (married vs single) | -9.3 (-17.9, -0.6) | 0.036 | -9.8 (-18.0, -1.6) | 0.019 | ||
| Time from baseline (1 month) | -0.37 (-0.72, -0.02) | 0.037 | -0.42 (-0.76, -0.08) | 0.014 | ||
|
| ||||||
| QOL-E, Fatigue | Age (1 year) | -0.17 (-0.33, -0.00) | 0.046 | -0.04 (-0.20, +0.11) | 0.57 | |
| Charlson’s index (2-5 vs 0-1)§ | -7.8 (-11.6, -3.9) | 0.0001 | -8.6 (-12.3, -4.8) | <0.0001 | ||
| Hb (1 g/dL)║ | +1.50 (+0.92, +2.07) | <0.0001 | +1.45 (+0.89, +2.01) | <0.0001 | ||
| Transfusions (yes vs no)¶ | -3.8 (-6.5, -1.2) | 0.0063 | -2.6 (-5.4, +0.2) | 0.064 | ||
| Gender (male vs female) | +2.0 (-1.4, +5.4) | 0.24 | +3.3 (+0.2, +6.4) | 0.038 | ||
| Time from baseline (1 month) | -0.08 (-0.23, +0.07) | 0.28 | -0.11 (-0.25, +0.04) | 0.16 | ||
|
| ||||||
| QOL-E, MDS specific | Age (1 year) | -0.21 (-0.42, +0.00) | 0.053 | -0.03 (-0.23, +0.17) | 0.80 | |
| Charlson’s index (2-5 vs 0-1)§ | -8.0 (-13.1, -3.0) | 0.0021 | -8.8 (-13.5, -4.1) | 0.0003 | ||
| Hb (1 g/dL)║ | +1.94 (+1.23, +2.65) | <0.0001 | +1.53 (+0.81, +2.26) | <0.0001 | ||
| Transfusions (yes vs no)¶ | -7.9 (-11.2, -4.6) | <0.0001 | -6.8 (-10.2, -3.5) | 0.0002 | ||
| Time from baseline (1 month) | -0.33 (-0.50, -0.16) | 0.0002 | -0.38 (-0.55, -0.22) | <0.0001 | ||
*
scaled from 0 (worst possible value) to 100 (best possible value);
†
variables with p<0.05 are included in the basic model, for other factors the reported p-value tests the addition to this model;
‡
mean difference of predicted dependent variable between levels (first - second) of binomial factors or for each 1-unit increase of quantitative factors;
§
at baseline;
║
at each visit;
¶
any transfusion within 3 months before the day of visit.