Table 1.
Physical and biochemical characteristics of the study subjects divided into insulin-sensitive and -resistant groups on the basis of their median whole-body insulin sensitivity
| Microarray | qPCR | |||||
|---|---|---|---|---|---|---|
| Insulin Sensitive | Insulin Resistant | p value | Insulin Sensitive |
Insulin Resistant | pvalue | |
| n | 5 | 5 | - | 11 | 9 | - |
| Age (years) | 33 ± 6 | 39 ± 5 | NS | 32 ± 4 | 39 ± 3 | NS |
| Body weight (kg) | 60 ± 4 | 90 ± 5 | 0.009 | 69 ± 4 | 90 ± 5 | 0.003 |
| BMI (kg/m2) | 22.0 ± 0.7 | 32.5 ± 1.7 | 0.009 | 24.7 ± 1.1 | 33.0 ± 2.0 | 0.002 |
| Whole-body fat (%) | 24 ± 3 | 36 ± 1 | 0.009 | 28 ± 2 | 36 ± 1 | 0.002 |
| Fat mass (kg) | 15 ± 2 | 33 ± 3 | 0.009 | 20 ± 2 | 35 ± 4 | 0.003 |
| Waist-to-hip ratio | 0.86 ± 0.02 | 0.93 ± 0.02 | 0.047 | 0.86 ± 0.01 | 0.91 ± 0.01 | 0.03 |
| fP-glucose (mmol/l) | 5.0 ± 0.1 | 5.7 ± 0.2 | 0.016 | 5.1 ± 0.1 | 5.6 ± 0.2 | 0.012 |
| fS-insulin (mU/l) | 3 ± 0.5 | 11 ± 2 | 0.009 | 3 ± 0.4 | 10 ± 1 | < 0.001 |
| fS-LDL cholesterol (mmol/l) | 2.2 ± 0.2 | 3.1 ± 0.2 | 0.016 | 2.2 ± 0.2 | 3.1 ± 0.2 | 0.004 |
| fS-triglycerides (mmol/l) | 0.9 ± 0.2 | 1.3 ± 0.2 | 0.076 | 0.78 ± 0.1 | 1.4 ± 0.2 | 0.002 |
| fS-HDL cholesterol (mmol/l) | 1.9 ± 0.09 | 1.4 ± 0.05 | 0.009 | 1.8 ± 0.08 | 1.4 ± 0.09 | 0.003 |
| fS-C-peptide (nmol/l) | 0.4 ± 0.03 | 0.8 ± 0.01 | 0.009 | 0.4 ± 0.03 | 0.8 ± 0.08 | 0.002 |
Data are mean ± SEM, fP = fasting plasma, fS = fasting serum