Table 5.

Ten most down-regulated pathways in insulin-resistant compared to insulin-sensitive group during euglycemic hyperinsulinemic conditions

GO category	Pathway name	Nominal p	Permuted p
GO:0005746	mitochondrial respiratory chain	9.7E-06	0.0002
GO:0044429	mitochondrial part	1.3E-05	0.001
GO:0022900	electron transport chain	1.6E-05	0.0002
GO:0050890	cognition	2.6E-05	0.0005
GO:0016651	oxidoreductase activity, acting on NADH or NADPH	3.9E-05	0.0002
GO:0005759	mitochondrial matrix	4.9E-05	0.0008
GO:0031349	positive regulation of defense response	7.3E-05	0.0008
GO:0022891	substrate-specific transmembrane transporter activity	8.9E-05	0.0022
GO:0003954	NADH dehydrogenase activity	1.0E-04	0.0023
GO:0055114	oxidation reduction	1.1E-04	0.0037