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. Author manuscript; available in PMC: 2012 Jun 27.
Published in final edited form as: Circulation. 2008 Apr 14;117(16):2096–2103. doi: 10.1161/CIRCULATIONAHA.107.746412

Figure 6.

Figure 6

NO production and inhibition of in-stent restenosis with immobilized AdiNOS vectors. A, Stainless steel mesh-immobilized AdiNOS results in more efficient NO production than MOI equivalents of free adenovirus. Relative NO production (per Griess assay) after transduction of A10 cells with unmodified AdiNOS (MOI range 1 to 500) or with 1.6×108 AdiNOS particles (corresponding to MOI of 60) tethered via PABT/PEI(PDT)/HL complex formation. B and C, Significant inhibition of in-stent restenosis with stent delivery of immobilized AdiNOS. Representative photomicrographs of arterial sections treated with control BMS (B) and AdiNOS-tethered stents (C). Verhoeffvan Gieson elastic stain, original magnification ×200.