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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Laryngoscope. 2011 Nov 22;122(1):174–189. doi: 10.1002/lary.22392

Figure 4. AR42 decreased tumor volumes in human vestibular schwannoma xenografts.

Figure 4

Figure 4

Figure 4

SCID-ICR mice were implanted in the left flank with fresh human VS specimens. A month following tumor implantation, the mice were given a baseline MRI and fed either normal rodent chow or AR42-containing chow. A final MRI sequence was taken 2 months afterward. (A) The change in volume for each mouse in the control group was plotted, showing a 6% mean increase in tumor volume across all mice. (B) Waterfall plot representing the change in volume for each mouse in the AR42-fed group revealed an overall decrease in tumor volume for the group (mean decrease ~ 28%). (C) Representative MR images from a control mouse and an AR42-fed mouse.