Figure 7. AR42 was well tolerated with no clinically significant abnormalities in organ tissue histology identified during 6-month of oral dosing.

The FVB/N mice described in Figure 6 were analyzed for histopathology across multiple organs. Shown are representative sections from the cerebral cortex, cardiac muscle, skeletal muscle, kidney, and liver. Mice fed AR42 chow for 3-months showed no detectable differences relative to control mice. Mice treated with AR42 for 6-months displayed centrilobular hepatocellular hypertrophy, a common adaptive response to xenobiotics.