Table 3.
Relationship between Antipsychotic Polypharmacy and Other Adverse Effects
| Increased Adverse Effects | Decreased Adverse Effects | ||||||
|---|---|---|---|---|---|---|---|
| Baseline Antipsychotic |
Augmenting Antipsychotic |
Studies | Baseline Antipsychotic |
Augmenting Antipsychotic |
Studies | ||
|
General side effects |
Mixed Mixed Risperidone/ Quetiapine Mixed |
Mixed Mixed Aripiprazole Mixed |
Barbui ’06 Centorrino ‘04 No effect: Kane ‘09 Ganesan ‘08 |
General side effects | None | - | - |
|
Sedation /somnolence |
Clozapine | Risperidone | Anil Yagcioglu ’05 | Sedation/hypersomnia | Clozapine-DR Clozapine-DR |
Ziprasidone Aripiprazole |
Ziegenbein ’05 Rocha & Hara ‘06 |
| Ileus | SGA Mixed |
SGA Mixed |
Brooks ‘11 No effect: Nielsen ‘10 |
Ileus | None | - | - |
|
Cognitive impairment |
Mixed Mixed Mixed Mixed |
Mixed Mixed Mixed Mixed |
Elie ‘10 Chakos ’06 Hori ’06 No effect: Kontis ’10 |
Cognitive impairment | None | - | - |
| Hypersalivation | Clozapine Clozapine Clozapine |
Mixed-FGA Sulpiride Risperidone |
Naber ’92 Henderson ‘96 No effect: Shiloh ’97 |
Hypersalivation | Clozapine-DR Clozapine |
Aripiprazole Amisulpiride |
Ziegenbein ‘05 Kreinin ‘06 |
|
Leukopenia, neutropenia agranulocytosis |
None | - | - |
Leukopenia, neutropenia agranulocytosis |
None | - | - |
| Seizures | None | - | - | Seizures | None | - | - |
|
Elevated liver enzymes |
None | - | - |
Elevated liver enzymes |
None | - | - |
Clozapine-DR: With concurrent “Dose Reduction” of clozapine