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. Author manuscript; available in PMC: 2012 Jun 27.
Published in final edited form as: Org Lett. 2007 Apr 24;9(11):2167–2170. doi: 10.1021/ol070658i

Table 1.

Pt(II)-Catalyzed 1,2-Dihydropyridine Synthesisa

entry substrate product yield(%)b
1 graphic file with name nihms-372100-t0008.jpg graphic file with name nihms-372100-t0009.jpg
a) R = Me 76
b) R = p-CIPh 72
c) R = tBu 76
d) R = Ph 76
2 graphic file with name nihms-372100-t0010.jpg graphic file with name nihms-372100-t0011.jpg 56
3 graphic file with name nihms-372100-t0012.jpg graphic file with name nihms-372100-t0013.jpg
a) R = cyclopropyl 62
b) R = Ph 69
c) R = H 70
4 graphic file with name nihms-372100-t0014.jpg graphic file with name nihms-372100-t0015.jpg 76
a

Standard conditions: 10 mol % of PtCl2, 0.2 M in PhMe at 100 °C over 3 h.

b

Isolated yields after column chromatography are reported.