Table 2.
Evidence from the package insert about age-related reduction in systemic clearance of antidepressants
| Class/Agent | Age-related reduction in clearance | Reference |
|---|---|---|
| MAOI | ||
| Isocarboxazid | N/A | |
| Phenelzine | N/A | |
| Selegiline | N/A | |
| Tranylcypromine | N/A | |
| Other Antidepressants | ||
| Bupropion | Yes | [45] |
| Mirtazapine | Yes* | [46] |
| Nefazodone | N/A | |
| Methylphenidate | N/A | |
| Trazodone | N/A | |
| Vilazodone | N/A | |
| SNRI | ||
| Desvenlafaxine | N/A | |
| Duloxetine | Yes+ | [47] |
| Venlafaxine | N/A | |
| SSRI | ||
| Citalopram | N/A | |
| Escitalopram | N/A | |
| Fluoxetine | N/A | |
| Paroxetine | N/A | |
| Sertraline | Yes | [48] |
| Tetracyclics | ||
| Amoxapine | N/A | |
| Maprotiline | N/A | |
| Trimipramine | N/A | |
| TCA | ||
| Amitriptyline | N/A | |
| Desipramine | N/A | |
| Doxepin | N/A | |
| Imipramine | N/A | |
| Nortriptyline | N/A |
*
Especially in males
+
tested only in females
Abbreviations: MAOI=monamine oxidase inhibitor; NA= none available; SNRI=selective norepinephrine reuptake inhibitor, SSRI= selective serotonin reuptake inhibitor; TCA=tricyclic antidepressant