Table 3.
Potential pharmacokinetic drug interactions with antidepressants from the scientific literature
| Class/Agent | Potential Interacting Drug | ↑ AUC or ↓ clearance | Reference |
|---|---|---|---|
| MAOI | |||
| Selegiline | Alprazolam | No | [49] |
| Selegiline | Cabergoline | Yes | [50] |
| Selegiline | Citalopram | No | [51] |
| Selegiline | Itraconazole | No | [52] |
| Selegiline | Olanzapine | No | [49] |
| Selegiline | Risperidone | No | [49] |
| Other Antidepressants | |||
| Bupropion | Cimetidine | Yes | [53] |
| Bupropion | Clopidogrel | Yes | [54] |
| Bupropion | Prasugrel | Yes | [55] |
| Bupropion | Ritonavir | Yes/No | [56, 57] |
| Bupropion | Ticlopidine | Yes | [54] |
| Mirtazapine | Amitriptyline | No | [58] |
| Mirtazapine | Cimetidine | Yes | [59] |
| Mirtazapine | Lithium | No | [60 ] |
| Mirtazapine | Paroxetine | Yes | [61] |
| Nefazodone | Cimetidine | Yes | [62] |
| Nefazodone | Desipramine | No | [63] |
| Nefazodone | Lithium | No | [64] |
| Nefazodone | Lorazepam | Yes | [65] |
| Trazodone | Clarithromycin | Yes | [66] |
| Trazodone | Ritonavir | Yes | [67] |
| SNRI | |||
| Duloxetine | Fluvoxamine | Yes | [68] |
| Duloxetine | Paroxetine | Yes | [69] |
| Venlafaxine | Cimetidine | Yes | [70] |
| Venlafaxine | Diphenhydramine | Yes* | [71] |
| Venlafaxine | Ketoconazole | Yes | [72] |
| Venlafaxine | Terbinafine | Yes | [73] |
| Venlafaxine | Voriconazole | Yes | [73] |
| SSRI | |||
| Citalopram | Ketoconazole | No | [74] |
| Escitalopram | Cimetidine | Yes | [75] |
| Escitalopram | Omeprazole | Yes | [75] |
| Escitalopram | Ritonavir | Yes | [76] |
| Fluoxetine | Alosetron | Yes | [77] |
| Fluoxetine | Desloratadine | Yes | [78] |
| Paroxetine | Cimetidine | Yes | [79] |
| Paroxetine | Terbinafine | Yes | [80] |
| Sertraline | Donepezil | No | [81] |
| TCA | |||
| Amitriptyline | Cimetidine | Yes | [82] |
| Amitriptyline | Diazepam | Yes | [83] |
| Amitriptyline | Divalproex | Yes | [84] |
| Amitriptyline | Fluvoxamine | No | [85] |
| Amitriptyline | Ketoconazole | Yes | [86] |
| Amitriptyline | Orlistat | No | [87] |
| Desipramine | Atomoxetine | No | [88] |
| Desipramine | Duloxetine | Yes* | [69] |
| Desipramine | Fluoxetine | Yes | [89,90] |
| Desipramine | Ketoconazole | No | [91] |
| Desipramine | Paroxetine | Yes* | [92,93] |
| Desipramine | Sertraline | Yes | [90,93] |
| Desipramine | Temsirolimus | Yes | [94] |
| Doxepin | Cimetidine | Yes | [95] |
| Imipramine | Cimetidine | Yes | [96–98] |
| Imipramine | Diltiazem | Yes | [99] |
| Imipramine | Fluoxetine | Yes | [101] |
| Imipramine | Labetolol | Yes | [99] |
| Imipramine | Ketoconazole | Yes | [91] |
| Imipramine | Paroxetine | Yes | [100] |
| Imipramine | Ranitidine | No | [97] |
| Imipramine | Verapamil | Yes | [99] |
| Nortriptyline | Cimetidine | No | [82,98] |
| Nortriptyline | Divalproex | Yes | [84] |
| Nortriptyline | Fluvoxamine | No | [85] |
| Nortriptyline | Paroxetine | Yes | [101] |
*
in extensive metabolizers only
Abbreviations: MAOI=monamine oxidase inhibitor; NA= none available; SNRI=selective norepinephrine reuptake inhibitor, SSRI= selective serotonin reuptake inhibitor; TCA=tricyclic antidepressant