Table 4.
Baseline Disease, Clinical, and MRI Characteristicsa
| Mean±SD | Median (Min, Max) | |
|---|---|---|
| Years since diagnosis | 1.2±3.3 | 0.0 (0-36) |
| Years of symptom | 4.3±5.6 | 2.0 (0-39) |
| Relapses prior 12 Months | 1.7±0.8 | 2.0 (0-6) |
| Relapses prior 3 Years | 2.5±1.0 | 2.0 (1-15) |
| EDSS | 2.1±1.2 | 2.0 (0-6.5)b |
| Rankin Score (1007) | 1.0±0.7 | 1.0 (0-3) |
| MSFC (1000) | ||
| 9 Hole Peg Test | 20.2±4.7 | 19.1 (11.5-86.5) |
| Timed 25Foot Walk | 5.0±1.6 | 4.7 (2.3-21.7) |
| PASAT-3 | 49.8±10.4 | 53.0 (0-60) |
| Contrast Letter Acuity (996), # correct | ||
| CLA 100% | 56.5±6.3 | 59.0 (0-60) |
| CLA 2.50% | 37.7±10.4 | 39.0 (0-60) |
| CLA 1.25% | 27.3±11.9 | 29.0 (0-60) |
| MRI characteristics | ||
| Number T2 Lesions | 87.6±56.1 | 71 (6-379) |
| Volume T2 Lesionsc | 10.5±11.5 | 6.4 (0.1-76.2) |
| Number Post Gd T1 Hypointense Lesions | 63.7±58.0 | 44 (0-423) |
| Volume Post Gd T1 Hypointense Lesions | 1.7±2.2 | 0.9 (0-12.4) |
| Burden of Disease (T2 + T1) | 12.2±13.2 | 7.5 (0.1-87.4) |
| Number Gd Lesions, all subjectsd | 1.7±4.2 | 0 (0-41) |
| Volume Gd Lesionse | 0.3±0.5 | 0.1 (0.002-4.3) |
| Number (%) subjects with Gd Lesion | 399 (39.6) |
a
N = 1008, unless noted
b
Two participants with protocol violation EDSS of 6 and 6.5 at entry
c
all volumes are in ml
d
1 participant received partial Gadolinium
e
in subjects with Gd lesions