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. Author manuscript; available in PMC: 2012 Jun 27.
Published in final edited form as: Open Biol J. 2012 May 4;5:6–16. doi: 10.2174/1874196701205010006

Fig. (3).

Fig. (3)

Results of molecular dynamics simulation of putative AVEN BH3 motif with BCL-xL. (A). Ribbon diagram of a peptide encompassing the putative BH3 motif of human AVEN (ESQRGTDFSVLLSSAGDSFSQFRFA; shown in red) complexed with BCL-xL. (B) Ribbon diagram of the corresponding peptide from Drosophila Aven (AQLRAGDFQQLAQFPSLGGGHFTFG; shown in red). See Fig. 1 and text for details. Simulations (20 ns) are based on an analogous 25-mer of the BAD BH3 motif and the BAD/BCL-xL structure (PDB code: 1G5J).