Fig. (4).

Known and hypothetical interactions between selected autophagy, DNA damage checkpoint, and apoptotic proteins. Known physical associations for ATG12, ATG16L1, AVEN and BECN1 were imported from BioGrid (http://thebiogrid.org/). Binding of ATG12 to BCL2 via a BH3-like motif was reported in Ref. [100]. A putative interaction between ATG16L1 and a representative anti-apoptotic BCL2 family member (BCL2) is indicated. Proteins highlighted in red were recovered in the screen for new BH3-containing protein candidates.