Figure 1. Regulatory network linking sRNAs to virulence in V. cholerae. Extracellular signal inputs coordinate regulatory cascades that connect the transcription of multiple sRNAs to the expression of genes that play a role in V. cholerae virulence. Sensory information is perceived by cognate receptors in or at the bacterial membrane (left), which transduce information into the regulatory network of the cell. Transcription of multiple sRNAs (boxed) is altered, resulting in changes in the expression of numerous genes involved in virulence and pathogenesis (right). The signal(s) sensed by VarS remains unclear. Dashed lines indicate indirect regulation. Solid lines indicate direct regulation. See text for additional details.