Table 1b. Five sRNAs involved in virulence of S. Typhimurium.
sRNA name | Target mRNA | Role in virulence | References |
---|---|---|---|
IsrJ |
|
Control of effector protein production |
32 |
IsrM |
hilE, sopA |
Modulates the expression of SPI1 proteins via hilE; downregulates SopA |
57 |
IstR |
tisAB |
SOS induced toxic peptide – Inhibits growth allowing DNA repair |
62,61 |
OxyS |
Regulates about 40 genes; including rpoS |
Inhibits alternate stress adaptation pathways during oxidative stress |
20,32,61 |
SroA | Riboswitch element of the thiBPQ operon | Putative import of Thiamine and Thiamine pyrophosphate | 61 |