Figure 2. Centrosomal protein and microtubule organization in the epidermis. In basal cells of the epidermis, microtubules are organized in a radial array around an apically localized centrosome. Lis1, Ndel1, and ninein localize at the centrosome. In the differentiated suprabasal cells where desmosomes are robust, Lis1, Ndel1, and ninein are lost from the centrosome and are recruited to the desmosome by desmoplakin, along with CLIP170. Microtubules are organized around the cell cortex.