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Figure 2. Secondary structures of selected human mitochondrial tRNAs with pathogenesis-related T-loop mutations (Reference Mamit with updates from Mitomap). The T-loop substitutions are assigned canonical nt #s with the mitochondrial reference sequence numbers in (). (A) tRNALeu(UUR) 56C > A (3287C > A), 57A > G (3288A > G), 60U > C (3291U > C); (B) tRNAIle 59A > G (4317A > G); (C) tRNAGly 59A > G (10044C > G); (D) tRNAHis 59G > A (12192G > A).
