Table 4. Association results of rs1063192 and rs7916697 in different models.
| SNPs | rs1063192 | (CDKN2B) | rs7916697 | (ATOH7) | ||
| Phenotype | POAG (n = 272) | Controls (n = 165) | POAG (n = 271∧) | Controls (n = 165) | ||
| Allelic Analysis | ||||||
| Alleles (%) | T* | 523 (96.1%) | 299 (90.6%) | A* | 410 (76%) | 223 (68%) |
| C | 21 (3.9%) | 31 (9.4%) | G | 132 (24%) | 107 (32%) | |
| HWE P | 0.51 | 0.68 | 0.20 | 0.40 | ||
| P1 | OR2 (95% CI) | P1 | OR2 (95% CI) | |||
| Allelic P Values | 0.0008 | 0.39 (0.22−0.69) | 0.0096 | 0.67 (0.50−0.91) | ||
| Genotypic and Model Based Analysis | ||||||
| Genotypes (%) | TT | 251 (92%) | 135 (82%) | AA | 159 (59%) | 73 (44%) |
| TC | 21 (8%) | 29 (18%) | AG | 92 (34%) | 77 (47%) | |
| CC | 0 (0%) | 1 (1%) | GG | 20 (7%) | 15 (9%) | |
| P | OR (95% CI) | P | OR (95% CI) | |||
| Additive (Trend) | 0.0007 | 0.0106 | ||||
| Dominant | 0.00096 | 0.38 (0.21−0.68) | 0.0034 | 0.56 (0.38−0.83) | ||
| Recessive | 0.6771 | n/a3 | 0.9901 | 0.80 (0.40−1.60) | ||
∧
One sample did not amplify when this marker was tested.
*
risk allele, odds ratios are calculated for the minor (protective) allele and genotypes.
1
Chi-Squared P-value. The Bonferroni corrected significance level was 0.0021 ( = 0.05/24, for 18 allelic tests for individual SNPs and 3 model specific tests for each of 2 SNPs).
2
Odds ratio.
3
no individuals were homozygous for the risk allele.