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. Author manuscript; available in PMC: 2012 Oct 31.
Published in final edited form as: J Ethnopharmacol. 2011 Sep 6;138(1):111–118. doi: 10.1016/j.jep.2011.08.058

Figure 5. Influence of berberine on major Cyp enzyme activities in livers of mice.

Figure 5

The major Cyp enzyme activities in mice were quantified after 2-weeks of daily berberine treatment. (A) Dextromethorphan O-demethylation was used as a marker for Cyp2d. The highest dose of berberine inhibited dextromethorphan O-demethylation 32.4%. (B) Testosterone 6β-hydroxylation was used as a marker for Cyp3a11/13 activity. The highest dose of berberine decreased testosterone 6β-hydroxylation by 67.9%. (C) The metabolism of 7-ethoxyresorufin O-dealkylation was the marker for Cyp1a1/2 activity. (D) Testosterone 15α-hydroxylation was used as the marker for Cyp2a4. (E) Testosterone 16β-hydroxylation was used as the marker for Cyp2b10 and Cyp2c29 activities.