Figure 2.

Immunohistochemical results and electrode microwire placement. (A) Coronal section of the substantia nigra pars compacta (SNpc) illustrating immunohistochemistry of tyrosine hydroxylase (TH). Note the lack of TH staining in the SNpc of the lesioned (left) hemisphere compared with the non-lesioned (right) hemisphere. Location of section: bregma = −5.04 mm (Paxinos and Watson, 1986). Mean loss of TH+ stained = 86%, range = 76–97%. (B) Coronal section of the substantia nigra pars reticulata (SNpr) illustrating microwire placement. Sections were stained with cresyl violet and potassium ferricyanide to reveal the iron deposits; recording sites are indicated by arrows. Note the small electrolytic lesion clearly evident in the right section. Location of section: left figure, bregma = −5.02 mm and right figure, bregma = −5.28 mm (Paxinos and Watson, 1986). Scale bars: 1 mm