Figure 5A. mRNA expression of (a) ER-α, (b) ER-β, (c) PR and (d) ER-α/ER-β ratio in the endometrium of 28-week-old wildtype and Pten+/− mice fed control diet, VD3 supplemented control diet, OID, or VD3 supplemented OID for 24 weeks. ER-α mRNA levels were significantly higher in Pten+/− mice fed the control diet than in the wildtype mice; *p<0.014. No changes among different dietary exposures were seen. Mean ± SEM of 5–7 mice per group are shown.
Figure 5B. Endometrial protein levels of (a) ER-α and (b) PR in the luminal and glandular epithelium and stroma of 28-week-old wildtype and Pten+/− mice. PR expression was significantly lower in the luminal epithelium of Pten+/− mice than of the wildtype mice (p<0.04). Mean ± SEM of 3–10 mice per group are shown.