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RYR effects on gene expression involved in androgen synthesis. RYR-fed animals downregulated HSD3B2 (A), AKR1C3 (B) and SRD5A1 (C) gene expression by more than three and two folds in LNCaP and LNCaP-AR SCID tumors. Values are Mean ± SE. *: Significantly different from control at P<0.05.