Table 1.
| Study | cases n | # of dups. | % | controls n | # of dups. | % | size (kb) | UCSC Build HG18 | Odds Ratio | p-val |
|---|---|---|---|---|---|---|---|---|---|---|
| NIMH COS1 | 92 | 2 | 2.17% | 2026*2 | 0 | 0.00% | 143-216 | chr2:1618945-1835426 | NA | 0.002 |
| chr2:1713636-1857129 | ||||||||||
|
| ||||||||||
| other studies | ||||||||||
|
| ||||||||||
| Vrijenhoek et al 20083 | 806 | 2 | 0.25% | 706 | 0 | 0.00% | 967-3800 | chr2:859616-1826716 | NA | 0.5 |
| chr2:1400000-4500000 | ||||||||||
| ISC 20084 | 3391 | 3 | 0.09% | 3181 | 1 | 0.03% | 103-238 | chr2:1712998-1815909 | 2.8 | 0.63 |
| chr2:1712998-1922382 | ||||||||||
| chr2:1716437-1826717 | ||||||||||
| Kirov et al 20095 | 471 | 1 | 0.21% | 2792 | 0 | 0.00% | 484 | chr2:1785886-2269413 | NA | 0.14 |
| Ikeda et al 20106 | 575 | 1 | 0.17% | 564 | 0 | 0.00% | 855 | chr2:987335-1842013 | NA | 1 |
|
| ||||||||||
| Totals | ||||||||||
|
| ||||||||||
| total other studies | 5233 | 7 | 0.13% | 7253 | 1 | 0.01% | 9.7 | 0.01 | ||
| total all 5 studies | 5325 | 9 | 0.17% | 9279 | 1 | 0.01% | 15.7 | 0.001 | ||
|
| ||||||||||
| COS vs. other studies | ||||||||||
|
| ||||||||||
| COS vs. AOS7 | 92 | 2 | 2.17% | 5233 | 7 | 0.13% | 16.6 | 0.01 | ||
1
Affymetrix 500K arrays and Agilent 185K or 244K CGH (for validation); mixed ancestry; Walsh et al. 2008
*2
Illumina HumanHap 550 arrays; 2/3 Caucasian, 1/3 African-American ancestry; controls from Children’s Hospital Of Philadelphia (CHOP) CNV database (cnv.chop.edu)
3
Affymetrix 250K or Illumina HumanHap550v3 arrays; Dutch ancestry from GROUP (Genetic Risk and Outcome I Psychosis) Consortium
4
Affymetrix 5.0 or 6.0 arrays; 7 populations of European ancestry
5
Affymetrix 500K arrays; WTCCC (Wellcome Trust Case Control Consortium)
6
Affymetrix 5.0 arrays, Japanese ancestry
7
COS=childhood onset schizophrenia; AOS=adult onset schizophrenia