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. 2011 Oct 18;152(12):4974–4983. doi: 10.1210/en.2011-1182

Table 1.

microRNA differentially expressed in control vs. T- or T plus flutamide-treated fetal ovine ovaries

miRNA C vs. T FC C vs. TF FC Functional analysis literature based$ Predicted targets (Targetscan)
miR-497 3.83 3.71 Type 2 diabetes rat [miR-15b/497 family (1) PAPPA, IR, GHR, IGF2R, IRS2, IGF1R, furin
miR-29a 2.98 Diabetes/insulin signaling (15), FSH regulated (6) IGF1, INSIG1, leptin
miR-192 2.19 Diabetic neuropathy (4, 7, 8) IGF1
miR-24-2* 2.12 Diabetes (9), Insulin signaling (10), bovine ovary (11) INSIG1, PPARa, Furin, IGFBP5, IGF2BP2
miR-15b 2.06 2.93 Type 2 diabetes rat FSH (1), regulated in ovary (6) PAPPA, IR, GHR, IGF2R, IRS2, IGF1R, furin
miR-101 1.90 AR regulated (12) PGRMC2, PPARa
miR-212 1.87 LH regulated in ovary (13)
miR-451 1.85 Sex dependent in liver (14)
miR-186 1.82 Type 1 diabetes (15) INSM1, LEPR, IGF1, IGF1R
miR-672 1.82 Mouse ovary (16) IGF1R
miR-7 1.67 Insulin signaling (17, 18) IRS2, IRS1, IGF1R, PAPPA
miR-30b-5p 1.58 Estrogen regulated (19) LEPR, IGF2R, INSIG2, IRS1, IRS2, LDLR, IGF1R, IGF1
miR-22* 1.52 Fetal ovine gonad (20), androgen regulated (21), represses ESR1 (22) ESR1, GHRHR, PTGS1, IGF2BP1, furin
miR-378 −4.13 Lipid/fatty acid metabolism (23), regulates estrogen production (24)
miR-760 −2.80 Estrogen regulated (25) IR
miR-10a −2.76 −3.36 Androgen regulated (26), ovary (27) PPARa
miR-182 −2.71 Insulin signaling (10), ovary (27) INSIG1, IGF2BP1
miR-129* −2.22 Diabetes (28) IGF1, GHR, ESR1, INSIG2
miR-132 −1.82 LH regulated in ovary (13)
miR-223 −1.69 Diabetes (9) IGF1R
miR-363 4.50 Sex differentiation (29) PTGER4, IRS2, INSIG1
miR-20b 3.24 Diabetes (9), ESR1 regulated (30) PPARa, LDLR, IGF2BP1, ADIPOR2, PPARd
miR-330 1.71 Fetal programming (31) IGF2BP1
miR-29c 1.64 Diabetic neuropathy (32), diabetes (2) IGF1, INSIG1, leptin
miR-29b 1.62 Diabetes (2, 9), sex dependent in liver (14) IGF1, INSIG1, leptin
miR-191* 1.56 Diabetes (9)
miR-101a* 1.53 AR regulated (12) PGRMC2, PPARa
miR-105 1.52 Human ovary (27)
miR-133a −1.85 Insulin signaling (33, 34) IR, IGF1R

C, Control; ER, estrogen receptor; FC, Fold change; TF, testosterone + flutamide.

References for table are included in the Supplemental Online Materials.

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