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. 2012 Jun 28;3:176. doi: 10.3389/fimmu.2012.00176

Table 1.

Estimate of the maximum size of sequence collections that can be processed.

Excel version Operation system Max. memory No. of sequences
Excel 2003 Windows XP 1 Gigabyte ∼40,000
Windows 7 (32/64-bit)
Excel 2007 Windows XP 2 Gigabyte ∼60,000
Excel 2010 (32-bit) Windows 7 (32/64-bit)
Excel 2010 (64-bit) Windows 7 (64-bit) 8 Terabyte 150,000 (max. no. of IMGT/HighV-QUEST)

The restrictions are caused by limited addressable memory by Excel. Excel versions prior 2007 can not address more than 1 GB of memory. 32-bit versions of Excel 2007/2010 can use 2 GB of memory, while the 64-bit versions are virtually unrestricted.