Table 2.

Pharmacokinetic and pharmacodynamic variables involved in the administration of perioperative cancer chemotherapy in peritoneal surface malignancy patients.

Pharmacokinetic variables	Pharmacodynamic variables
Dose	Temperature
Volume	Nodule size of residual tumor
Duration	Density
Carrier solution	Binding
Pressure	Interstitial fluid pressure
Vasoactive agents	Charge
Macromolecular vehicles	Vascularity