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Elements of Ca2+ signaling machinery implicated in HIV-1 release. Tsg101-mediated release requires the core elements, IP3R, PI(4,5)P2, and PLC. Alix-mediated release requires these, SOCE and ROCE. It is not known whether SOCE and ROCE are controlled by distinct Ca2+ channels [120] or if the same channel complexes mediate SOCE when recruited to lipid rafts and ROCE when they are outside of lipid rafts [121].
